I searched Google for "wine cdrom". This thread at eeeuser
Also, when temporarily mounting .iso files, I like to use something like "fuseiso -p /tmp/iso_folder iso_file.iso". You'll need to install "fuseiso", "sudo apt-get install fuseiso" should do it. FUSE (Filesystem in Userspace) mounting doesn't require "sudo" and the command I gave will automatically create the directory and automatically remove it when the iso is unmounted ("fusermount -u /tmp/iso_folder"). So, it's more convenient for temporary .iso mounting.
Finally, just so you're aware, copy protection schemes can use data stored on a disc outside of the "ISO" area. So, a simple .iso can fail on copy-protected games, unless your mounter can spoof the copy-protection. Linux .iso mounting lacks copy-protection spoofing.