Ok so I did the combo update as I'm already running 10.6.2 so no system updates just programs. After the update is successful it just seems to hang so I restart manually. When the restart happens looks like it's going to boot normal but the screen goes gray after the Apple splash screen and spinner finish. PANIC!!! I restart again, same thing. Two more restarts and it's the same, even got a kernal panic on one of the restarts, CRAP!!! I stepped away for a couple minutes and come back to a blue screen, like it's starting up but it's just blue (This is after seeing the gray screen but just left it running). I decided to leave it on for a couple more minutes and then the login screen appears, YEAH!!!.
So just a FYI, let your computer run and don't panic if you see the Grey Screen of Death. Looks like it just loads a little slower on the initial upgrade. After that I did another restart and things look back to normal, Heart is beating normal again