Yes, it works fine in OS X, both for install and after installation is complete. For best results, plug usb cord into usb port nearest the power connection.
IMHO, best drive for the money. It is the same footprint as the whole mini, but I just set my mini on top of the drive during OS installs.
Mini 9 | OS X 10.6.7 | NBI 20100616212351| BIOS 05 | 32 GB Runcore | 2 GIGS RAM
10V | OS X 10.6.7 | NBI 20100616212351 |BIOS 06|160 GB|1 GIG RAM| 6 Cell Dell Battery
Back up Mini 9| OS X 10.6.7| NBI 20100616212351| BIOS 05 | 32 GB SuperTalent | 2 GIGS RAM