Yes you can . I have installed it in mine. Cubase Essential 4, Acid 7, Orion, Reason Adapted and all programs works perfect. I have run 4 VSTi within Cubase and no problem, if you want to run more VSTi, Cubase have a Freeze function. But if you donĀ“t have Cubase, you can record to wav some VSTi track and load more. I did`nt checked yet how many audio track can run, but in ACID at least i have run 10 audio tracks. These machine is perfect for audio, the only problem is the overheating, but i will buy a cooler.